Correlation Between Invariable Blood Proteins and Heart Rate Variability in Long-Duration Space Flights-Reference-Cited by-同舟云学术

Correlation Between Invariable Blood Proteins and Heart Rate Variability in Long-Duration Space Flights

Published:2024-07-29 Issue: Volume: Page:
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Author:

Pastushkova Ludmila¹,Rusanov Vasily¹,Goncharova Anna¹,Kashirina Darya¹,Nosovsky Andrey¹,Luchitskaya Elena¹,Krapivnitskaya Tatyana²,Larina Irina¹

Affiliation:

1. Institute of Biomedical Problems

2. Russian Medical Academy of Continuous Professional Education

Abstract

The article analyzes how long-duration space missions effect on the heart rate variability parameters and invariable blood proteins. The results are discussed taking into correlation between them. Seven Russian cosmonauts took part in the research during their missions to the International Space Station. Samples of dry blood drops were collected as part of the space experiment ''OMICs-SPK'', electrocardiogram samples were collected as part of the space experiment "Cardiovector". It was established a linear relationship between the concentrations of some proteins and spectral analysis parameters of heart rate at all stages of space flight. In the context of the physiological cardiovascular regulation, the linear correlation found between the six invariant proteins and HRV may be evidence of how and to what extent an adaptive regulation system provides flexible control over the periphery when several processes influence each other. The heart rate variability provides high adaptability, which makes it possible to quickly cope with the challenges of an aggressive and changing environment, maintain homeostatic processes and provide valuable information about the body's ability to function effectively in microgravity.

Publisher

Springer Science and Business Media LLC

Reference41 articles.

1. Grigoriev, A.I.: The concept of health and space medicine / A.I. Grigoriev, R.M. Bayevsky; Institute of Biomedical Problems of the Russian Academy of Sciences. – Moscow: Slovo, – 207 p. (2007)

2. Larina, I.M., et al.: Innovative proteomic research in cardiology applied to occupational health problems in aerospace medicine / I.M. Larina, L.H. Pastushkova, Yu.I. Voronkov // Cardiological bulletin. – – vol. 15, No. S. – pp. 10–11. (2020)

3. Larina, I.M. Proteomic research of human liquids from the Russian Segment of the International Space Station taken before and after orbital flights. A decade of research experience: monograph /, Larina, I.M., Pastushkova, L.H., Goncharova, A.G.: – Moscow: IBMP RAS, – 83 p. (2021)

4. Rea, G., et al.: Microgravity-driven remodeling of the proteome reveals insights into molecular mechanisms and signal networks involved in response to the space flight environment / G. Rea, F. Cristofaro, G. Pani // Journal of proteomics. –. – Vol. 137. – P. 3–18. (2016)

5. Schmidt, M.A.: Personalized medicine in human space flight: using Omics based analyses to develop individualized countermeasures that enhance astronaut safety and performance / M.A. Schmidt, T.J. Goodwin // Metabolomics. – 2013. – Vol. 9. – P. 1134–1156