Targeting the Warburg Effect with Glucosodiene: A Case Report of a 43-year-old Female after Mastectomy of the right breast and axillary clearance with Successful First Case Treatment for Metastatic Triple Negative Breast Cancer (TNBC) of Bone.

Abstract

Abstract Breast cancer is the most common type of cancer among women, and triple-negative breast cancer (TNBC) is a particularly aggressive subtype, representing 15-20% of cases. TNBC lacks estrogen, progesterone, and HER2 receptors, making it challenging to treat. This study explores a novel approach by investigating the metabolic pathways in TNBC, focusing on the alkaline glucose isomer, glucosodiene, as a potential therapy. The Warburg effect, discovered in 1924, serves as the basis for this investigation. The case report presents a 42-year-old female patient with TNBC Patient with MRM, Modified radical mastectomy, With axillary clearance., exhibiting a right breast lump with lymph node metastasis. Diagnostic tests confirmed invasive ductal carcinoma GII with negative hormone receptors and HER2/neu. The patient had previously undergone unsuccessful traditional chemotherapy and presented with bone metastasis. Treatment with glucosodiene for 15 days resulted in normal vital functions and no signs of cellular activity. This case study aims to evaluate an individualized treatment plan for TNBC patients and establish effective follow-up protocols. The trial is registered under clinicaltrials.gov number NCT05957939.