Association Between Platelet-to-lymphocyte ratio(PLR) And Serum Prostate Specific Antigen (PSA) Among U.S. Males

Abstract

Abstract Background The evidence suggests that the systemic inflammatory response may influence Prostate-specific antigen (PSA) concentrations. The relationship between platelet-to-lymphocyte ratio (PLR) and PSA, on the other hand, remains contradictory. As a result, we examined the relationship between PLR and PSA using the National Health and Nutrition Examination Survey (NHANES) database. Methods After the screening, 6,638 participants out of 52,195 in the NHANES survey from 2001 to 2010 were suitable for our study. The PLR was the independent variable in our study, and PSA was the dependent variable. Results The selected subjects in our study had an average age of 58.563 years (± 11.848 years). After controlling for covariates, the results showed that for everyone increase in PLR, the PSA concentration increased by 0.004 ng/mL (0.001, 0.007), and the difference was statistically significant. Furthermore, we created a smoothing curve based on a fully adjusted model to investigate the possibility of a linear relationship between PLR and PSA concentration. Conclusion PLR is independently and positively correlated with PSA in American men. Due to detection bias, the specificity of detecting asymptomatic prostate cancer improves in populations with low PLR, whereas in people with high PLR, it may predispose to over-diagnosis of asymptomatic prostate cancer.