Affiliation:
1. Australian National University
2. Ministry of Health and Sanitation
Abstract
Abstract
Background
COVID-19 vaccine coverage in low- and middle-income countries continues to be challenging. As supplies increase, coverage is increasingly becoming determined by rollout capacity.
Methods
We developed a deterministic compartmental model of COVID-19 transmission to explore how age-, risk-, and dose-specific vaccine prioritisation strategies can minimise severe outcomes of COVID-19 in Sierra Leone.
Results
Prioritising booster doses to older adults and adults with comorbidities could reduce the incidence of severe disease by 21% and deaths by 32% compared to the use of these doses as primary doses for all adults. Providing a booster dose to pregnant women who present to antenatal care could prevent 39% of neonatal deaths associated with COVID-19 infection during pregnancy. The vaccination of children is not justified unless there is sufficient supply to not affect doses delivered to adults.
Conclusions
Our paper supports current WHO SAGE vaccine prioritisation guidelines (released January 2022). Individuals who are at the highest risk of developing severe outcomes should be prioritised, and opportunistic vaccination strategies considered in settings with limited rollout capacity.
Publisher
Research Square Platform LLC
Reference36 articles.
1. An equitable roadmap for ending the COVID-19 pandemic;Mukaigawara M;Nat Med,2022
2. An interactive web-based dashboard to track COVID-19 in real time;Dong E;Lancet Infect Dis,2020
3. World Health Organization. WHO SAGE roadmap for prioritizing uses of COVID-19 vaccines: an approach to optimize the global impact of COVID-19 vaccines, based on public health goals, global and national equity, and vaccine access and coverage scenarios, first issued 20 October 2020, updated: 13 November 2020, updated: 16 July 2021, latest update: 21 January 2022. In. Geneva: World Health Organization; 2022.
4. Models of COVID-19 vaccine prioritisation: a systematic literature search and narrative review;Saadi N;BMC Med,2021
5. Within-country age-based prioritisation, global allocation, and public health impact of a vaccine against SARS-CoV-2: A mathematical modelling analysis;Hogan AB;Vaccine,2021
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献