Quantitative Dynamic Contrast-Enhance MRI Parameters for Rectal Carcinoma Characterization: Correlation with Tumor Tissue Composition
Author:
Yuan Jie1, Liu Kun1, Zhang Yun1, Yang Yuchan1, Xu Huihui1, Han Gang1, Lyu Hua1, Liu Mengxiao2, Tan Wenli1, Feng Zhen1, Gong Hangjun1, Zhan Songhua1
Affiliation:
1. Shuguang Hospital, Shanghai University of Traditional Chinese Medicine 2. MR scientific Marketing, Siemens Healthineers Ltd
Abstract
Abstract
Objective
To investigate the relationship between dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) measurements and the potential composition of rectal carcinoma.
Methods
Twenty-four patients provide informed consent for this study. DCE MRI was performed before total mesorectal excision. Quantitative parameters were calculated based on a modified Tofts model. Whole-mount immunohistochemistry and Masson staining sections were generated and digitized at histological resolution. The percentage of tissue components area was measured. Pearson correlation analysis was used to evaluate the correlations between pathological parameters and DCE MRI parameters.
Results
On the World Health Organization (WHO) grading scale, there were significant differences in extracellular extravascular space (Ktrans) (F = 9.890, P = 0.001), mean transit time (MTT) (F = 9.890, P = 0.038), CDX-2 (F = 4.935, P = 0.018) and Ki-67 (F = 4.131, P = 0.031) among G1, G2, and G3. ECV showed significant differences in extramural venous invasion (t=-2.113, P = 0.046). Ktrans was strongly positively correlated with CD34 (r = 0.708, P = 0.000) and moderately positively correlated with vimentin (r = 0.450, P = 0.027). Interstitial volume (Ve) was moderately positively correlated with Masson’s (r = 0.548, P = 0.006) and vimentin (r = 0.417, P = 0.043). There was a moderate negative correlation between Ve and CDX-2 (r=-0.441, P = 0.031). The rate constant from extracellular extravascular space to blood plasma (Kep) showed a strong positive correlation with CD34 expression (r = 0.622, P = 0.001). ECV showed a moderate negative correlation with CDX-2 (r=-0.472, P = 0.020) and a moderate positive correlation with collagen fibers (r = 0.558, P = 0.005).
Conclusion
The dynamic contrast-enhanced MRI-derived parameters measured in rectal cancer were significantly correlated with the proportion of histological components. This may serve as an optimal imaging biomarker to identify tumor tissue components.
Publisher
Research Square Platform LLC
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