Effect of Tafluprost on Endothelial Function-related Molecules and Hemorheological Parameters in Patients with Primary Open-angle Glaucoma

Abstract

Abstract Objectives This study analyzed the effect of tafluprost on endothelial function-related molecules and hemorheological parameters in patients with primary open-angle glaucoma, and provided reference for clinical treatment.Methods Patients with primary open-angle glaucoma diagnosed and treated in our hospital from January 2018 to March 2019 were selected as the research subjects. 70 patients (140 eyes) were randomly divided into two groups: control group (n = 35 cases, 70 eyes) and observation group (n = 35 cases, 70 eyes). The patients in the control group received timolol maleate eye drops, and the patients in the observation group received tafluprost eye drops. The clinical effects of the two groups of patients were analyzed, and the changes of endothelial function-related molecule [vascular endothelial growth factor (VEGF) level] were detected before and after treatment, and the changes of blood rheology parameters before and after treatment in the two groups were analyzed.Results The total effective rate of the observation group was significantly higher than that of the control group (P < 0.05). After treatment, the visual acuity of the two groups was significantly increased while the intraocular pressure (IOP) was significantly decreased (P < 0.05), and the levels of VEGF and its receptors in serum were significantly increased (P < 0.05), End diastolic velocity (EDV) and peak systolic velocity (PSV) levels of central retinal artery (CRA) and short posterior ciliary artery (SPCA) were significantly increased while resistance index (RI) level was significantly decreased (P < 0.05). Compared with the control group, the above indicators in the observation group had more significant changes (P < 0.05).Conclusions Tafluprost has obvious clinical effect on patients with primary open-angle glaucoma, and can significantly improve abnormal hemorheological parameters and abnormal levels of endothelial function molecules.