Synthesis of magnetic luminescent nanoparticle Fe 3 O 4 @LaF 3 :Eu,Ag@APTES@β-CD, a potential carrier of ciprofloxacin and bioimaging agent

Abstract

Abstract Fe3O4@LaF3:Eu,Ag hybrid magnetic luminescent nanoparticles (NPs) were synthesized using a simple co-precipitation method and then functionalized with β-cyclodextrin (β-CD) using (3-aminopropyl)triethoxysilane (APTES). The chemical composition, crystalline nature, particle size, and surface morphology of the Fe3O4@LaF3:Eu,Ag@APTES@β-CD NPs were investigated, using powder X-ray diffraction, and high-resolution transmission electron microscopy. The uptake and release profiling of the LaF3:Eu,Ag@Fe3O4@β-CD NPs for the hydrophilic drug ciprofloxacin, showed 40 and 85% efficiency, respectively. The results indicated that the NPs have a high drug loading yield and a sustained drug releasing profile of the NPs, indicating that they can be used as a drug carrier. The photoluminescence spectral analysis of the NPs revealed their potentiality for use in bioimaging. Further analysis of the drug-loaded NPs (Fe3O4@LaF3:Eu,Ag@APTES@β-CD-ciprofloxacin) revealed, 100% microbial inhibition efficiency against Escherichia coli and Vibrio cholerae, and a minimum of 80% against Bacillus cereus.