Alginate-zein composite modified with metal organic framework for sulfasalazine delivery

Abstract

Abstract Metal-organic frameworks (MOFs) have promising prospects as drug nanocarrier, but are more limited in biomedical applications due to their poor stability and biocompatibility. To address this issue, sodium alginate-zein (MOF/SA-ZN) nanocomposites modified metal-organic framework was developed and used as an effective nanocarrier for sulfasalazine (SSZ) delivery. The obtained nanocomposite was structurally and morphologically characterized using different physicochemical techniques including Fourier transform infrared (FTIR), X-ray diffraction (XRD), and Field emission scanning electron microscopy (FESEM). Based on the results, the Zn2(BDC)2(DABCO) MOF were dispersed in biopolymers. The proposed nanocarrier leads to increased drug encapsulation and reduced side effects of SSZ, thus improving its bioavailability. In addition, the antibacterial properties of samples have been studied against Staphylococcus aureus and Pseudomonas aeruginosa. The results showed that the drug-loaded Zn-MOF/SA-ZN has a higher antibacterial activity against Staphylococcus aureus gram positive bacteria compared to SSZ. The current research provides a promising insight into the fabrication of polymer modified MOF based drug delivery platforms and antibacterial agents.