Affiliation:
1. Fuwai Hospital State Key Laboratory of Cardiovascular Disease
Abstract
Abstract
Epidemiological evidence suggests associations between exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular disease (CVD), while diabetes is a common risk factor on CVD. The present study aims to clarify the effect of high PAH exposure on diabetes and stroke in general population. A total of 7,849 individuals aged ≥ 20 years from the National Health and Nutrition Examination Survey 2007–2016 were included in the study. The logistic regression analysis modeled the association between PAH exposure and diabetes as well as stroke. The analysis yielded odds ratios (ORs) and 95% confidence intervals (CIs). The study also evaluated the potential mediating role of diabetes in the relation between PAH exposure and stroke via mediating effects analyses. Of the 7849 eligible participants, 1,424 cases of diabetes and 243 cases of stroke were recorded. After adjusting for covariates including age, gender, smoking status, education level, marital status, physical activity, hypertension, low-density lipoprotein cholesterol, and BMI, the ORs for stroke in the highest quartile (Q4) of total urinary PAHs were 1. 96 (95% CI: 1.11–3.46, P = 0.020) as compared to the lowest quartile (Q1) of total urinary PAHs. The ORs for diabetes in the Q4 of total urinary PAHs were 1.56 (95% CI: 1.15–2.11, P = 0.005). Additionally, the ORs between Q4 and Q1 for stroke and diabetes concerning exposure to 2-hydroxynaphthalene were 2.20 (95%CI: 1.18–4.07, P = 0.013) and 1.39 (95%CI: 1.07–1.82, P = 0.015) correspondingly. The mediation analysis found that diabetes accounted for 5.31% of the associations between urinary PAHs and the prevalence of stroke. Urinary metabolites of PAH have been linked to stroke and diabetes. Increasing the risk of diabetes may play a significant role in mediating the association between exposure to PAHs and increased risk of stroke. Monitoring and improving glucose metabolism in individuals with high exposure to PAHs may aid in reducing the prevalence of stroke.
Publisher
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