Uric acid/HDL-C Ratio May Predict Significant Coronary Artery Stenosis: Intravascular Ultrasonography Study

Abstract

Background: There may be severe difficulties in determining the severity of LMCA lesions. The use of intravascular ultrasound (IVUS) facilitates the decision about the lesion severity in these patients. The aim of this study was to investigate the relationship between UHR and lesion severity in patients who have undergone LMCA IVUS. Methods: The study included 205 patients who were determined with ICS in LMCA and underwent an IVUS procedure. In the IVUS measurements of these patients, the plaque burden (PB) and the minimal lumen area (MLA) showing lesion severity were measured. Results: The patients were separated into two groups according to the plaque burden values as those <65% and ≥65%. The UHR values were determined to be significantly higher in the high plaque burden group (479.5 vs. 428.6, p:0.001). When the patients were separated into two groups according to the MLA values (<6mm² and MLA ≥6mm²), the UHR values were determined to be significantly higher in the group with low MLA values (476.8 vs. 414.9, p<0.001). In the ROC analysis performed according to the MLA and plaque burden values, the UHR cutoff value of 450 was found to have similar sensitivity and the same specificity for both parameters. Conclusions: The results of this study suggested that there is a relationship between the UHR parameter and MLA <6mm² and plaque burden ≥65%, which are independently evaluated as critical in IVUS, and this could predict anatomically significant lesions in patients with a moderate degree of LMCA stricture.