Risk factors of chemotherapy-induced thrombocytopenia after oxaliplatin-containing chemotherapy for gastrointestinal malignancies

Abstract

Abstract Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia (CIT) in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. Grouped based on the presence or absence of CIT, univariate analysis was performed to identify significant factors related to chemotherapy-induced thrombocytopenia. Based on the results of multi-factor analysis, a nomogram was constructed using R language programing and its fitness was evaluated using the calibration curve and ROC curve. Results Univariate analysis identified 20 factors as closely related to CIT occurrence. The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT (P < 0.05): the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and natural killer (NK) cell count. The calibration curve of the monogram shows that the combined predictors had good consistency. A better prediction efficiency was observed with the ROC curve of 0.877 with the cut-off value of 0.3579613 (with sensitivity of 78.9% and specificity, 81.8%). Conclusion The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell count were independent risk factors for CIT.