Abstract
Objectives: The aim of this study was to determine the clinical and radiographic intraoral findings of patients with different types of amelogenesis imperfecta (AI).
Materials and methods: One hundred twenty-five individuals belonging to 103 Turkish families with AI who were admitted to İstanbul University Faculty of Dentistry Department of Pedodontics were examined between 2006 and 2018. Intraoral and extraoral examinations, intraoral radiographs and pedigrees of the cases were examined and genetic analyses were planned. All datas was included in the SPSS database and analyzed using the Chi-Square and Mann-Whitney U tests.
Results: The frequency of clinical and radiographic findings in different AI types was not statistically significant (p>0.05). Gene mutation was detected in different types of candidate genes in 32 families, While the presence of gene mutation was found to be statistically significant in different AI types (p<0.05), no significant difference was found between genetic mutations and consanguineous marriage (p>0.05).
Conclusions: AI is a complicated dental anomaly requiring long-term follow-up. Familial evaluation of the cases and complete radiographic and clinical controls are important for diagnosis and treatment.
Clinical revelance: This study emphasizes the importance of comprehensive and continuous assessment of patients with AI. By detailing intraoral and radiographic findings and identifying genetic mutations in various AI types, it aids clinicians in enhancing diagnostic accuracy and customizing treatment plans.