Affiliation:
1. University of Mohaghegh Ardabili
2. Torbat Heydariyeh University of Medical Sciences
3. Ardabil University of Medical Sciences
Abstract
Abstract
Purpose Gastric cancer (GC) as a multifactorial disease is caused by environmental, infectious, and genetic factors. The aberrant expression of lncRNAs has been considered as a crucial feature of human cancer. In this research, we assessed the expression levels of a linc00659 in GC patients.Methods Expression of linc00659 in tumor and non-tumor tissues (a total of 82 samples) was evaluated using qRT-PCR in Iranian patients. The correlation between the linc00659 expression levels and clinicopathological features was assessed.Results Linc00659 was down-regulated in more GC samples compared to controls, but we found no significant association between the linc00659 expression levels and GC risk [expression ratio of linc00659 in tumor tissues versus non-tumor tissues was 0.57 (p = 0.33)]. After classifying patients into down−/up-regulation groups, a significant association was observed between the linc00659 expression and origin of the tumor (p = 0.01).Conclusion We found a significant association of the linc00659 expression with origin of the tumor. Further investigations with large sample size are required to assess the linc00659 function in tumor genesis.
Publisher
Research Square Platform LLC
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