Affiliation:
1. American Dental Association Science & Research Institute, L.L.C
2. Hampton University
3. Hampden-Sydney College
4. University of Minnesota
5. Indian Institute of Technology
Abstract
Abstract
Orthopedic and dental implant failure continues to be a significant concern due to localized bacterial infections. Although previous studies have attempted to improve implant surfaces by modifying their texture and roughness or coating them with antibiotics to enhance antibacterial properties for implant longevity. However, these approaches have demonstrated limited effectiveness. In this study, we attempted to engineer the titanium (Ti) alloy surface biomimetically at the nanometer scale, inspired by the cicada wing nanostructure using alkaline hydrothermal treatment (AHT). The two modified surfaces of Ti plates were developed using 4 and 8-Hr AHT at 230oC. We found that the control plates showed a relatively smooth surface, with few artifacts on the surface. The results demonstrated a statistically significant decrease in the contact angle of the treated groups, which increased wettability characteristics. The 8-hour AHT group exhibited the highest wettability and significant increase in roughness 1.50 x 10-1 ± 0.029 µm (P<0.05), leading to more osteoblast cell attachment, reduced cytotoxicity effects, and enhanced relative survivability. The alkaline phosphatase activity measured in all different groups indicated that the 8-hour AHT group exhibited the highest activity, suggesting that the surface roughness and wettability of the treatment groups may have facilitated cell adhesion and attachment and subsequently increased secretion of extracellular matrix. Overall, the findings indicate that biomimetic nanotextured surfaces created by the AHT process have the potential to be translated as implant coatings or surface nano-texturing to enhance bone regeneration and implant integration.
Publisher
Research Square Platform LLC
Reference38 articles.
1. Prevalence of total hip and knee replacement in the United States;Kremers HM;The Journal of bone and joint surgery. American volume,2015
2. Trends in dental implant use in the US, 1999–2016, and projections to 2026;Elani H;Journal of dental research,2018
3. Etkin, C. & Springer, B. (Epub 2017/07/12, 2017).
4. The effects on bone cells of metal ions released from orthopaedic implants. A review;Sansone V;Clinical Cases in Mineral and Bone Metabolism,2013
5. Ibandronate and cementless total hip arthroplasty: densitometric measurement of periprosthetic bone mass and new therapeutic approach to the prevention of aseptic loosening;Muratore M;Clinical cases in mineral and bone metabolism,2012