The Combination of Astragalus Injection and Ambroxol Hydrochloride in the Adjuvant Treatment of COPD: A Systematic Review and Meta-Analysis

Abstract

Abstract In China, the combination of astragalus injection and ambroxol hydrochloride is used as an adjuvant treatment in chronic obstructive pulmonary disease (COPD). However, the effectiveness of combining astragalus injection and ambroxol hydrochloride as an adjuvant treatment for COPD has not been systematically evaluated. We performed a systematic review and meta-analysis to evaluate the efficacy of combining astragalus injection with ambroxol hydrochloride as an adjuvant treatment for COPD. The results of the meta-analysis indicated that the combination of astragalus injection with ambroxol hydrochloride as an adjuvant treatment can improve various clinical parameters in patients with COPD compared to conventional treatment alone. These parameters include the clinical effective rate, partial pressure of oxygen in artery, partial pressure of carbon dioxide in artery, forced expiratory volume in one second, percentage of forced expiratory volume in one second, forced vital capacity, and the ratio of forced expiratory volume in one second to forced vital capacity. However, further validation is required to evaluate the effectiveness of combining astragalus injection and ambroxol hydrochloride as an adjunctive treatment for patients with COPD.