The Bone Mineral Density of the Skull and its relation with Subdural Hematoma in Craniofacial Trauma in Women With Polycystic Ovary Syndrome (PCOS)

Abstract

Abstract Introduction: Subdural hematomas (SDHs) are common clinical entities after a traumatic brain injury (TBI). Due to the complicated pathophysiological mechanism of SDHs, the further clinical course of patients with SDHs is affected by pathological entities such as both global and focal ischemia beneath hematoma, reactive hyperemia/hyperperfusion, coagulopathy, delayed hematomas. The hormonal and metabolic imbalance that exists in women with polycystic ovary syndrome (PCOS) can have a positive and negative impact on bone mineral density (BMD). So far, a small number of studies with BMD estimation in women with PCOS have been performed and the results are heterogeneous, while several studies have reported that the prevalence of cerebrovascular risk factors is higher in women with PCOS. Aim To examine BMD in women with PCOS and the impact on the pathophysiological mechanism of SDH, and the tendency to craniofacial injuries with reference to laboratory and biochemical prognostic factors of patient outcomes. Material and methods We evaluated 48 women with PCOS (age: 25.35 ± 5.16 years) and 20 healthy women of the control group (CG), matched by BMI (age: 32.47 ± 5.70 years), cranium BMD, and homocysteine levels. Results There was a significant increase in the mean homocysteine level ​​(39 ± 1.36) in the PCOS group, and the BMD(Vault) (0.84 ± 0.11) as well. Conclusion Women with PCOS, matched by BMI and equalized by age, together with the homocysteine and BDM results, a correlation between PCOS and the occurrence of subdural hematoma exists. Prevalence of cerebrovascular risk factors is higher in women with PCOS due to higher homocysteine levels.