Cyr61 promotes inflammation in EtOH-induced RAW264.7 cell by regulating Wnt/β-catenin signaling pathway

Abstract

Abstract Growth factors induce Cysteine-rich 61 (Cyr61), a member of the Cyr61/CTGF/Nov (CCN) family of proteins, which interacts with a number of integrins and with the proteoglycans heparan sulfate. Cyr61 participates in angiogenesis, cell differentiation, death, and the production of the extracellular matrix. Recent data have shown that Cyr61 is a key chemokine in controlling inflammation and fibrosis in liver injury, but until recently, uncertainty surrounds Cyr61's part in alcoholic liver disease (ALD). This work investigated Cyr61 expression in RAW264.7 cells induced by EtOH and its impact on pertinent cell function. The findings showed that Cyr61 was increased in EtOH-induced RAW264.7 cells and that it may have an adverse effect on cell survival, stimulate the release of inflammatory cytokines, boost cell growth, and block apoptosis. The signaling pathway for Wnt and β-catenin may be activated as part of the mechanism. The involvement of Cyr61 in EtOH-induced RAW264.7 cells was disclosed by our investigation, offering a fresh target for the prevention and treatment of ALD.