Ocular Features of Pseudoxanthoma Elasticum Observed by Multispectral Imaging

Abstract

Abstract Clinically there are controversies on the nature of peau d'orange change in pseudoxanthoma elasticum (PXE). It was originally described as pigmentary changes due to the dark spots under funduscopic examination, but later other features by infra-red image, autofluorescence and spectral-domain OCT indicated the lack of pigment clumping activity in the outer retina. We recently developed light-emitting-diode-based multispectral imaging system for investigation of ocular pigment changes and, in this study, we enrolled PXE chorioretinopathy as a pilot case to demonstrate its ability of revealing spectrum-sensitive imaging features of MSI.