Predictive value of 4’-[methyl-11C]-thiothymidine PET volumetric parameters for local control in p16-negative oropharyngeal, hypopharyngeal, and supraglottic squamous cell carcinoma

Author:

Ouchi Yohei1ORCID,Kishino Takehito1,Miyashita Takenori1,Mori Terushige1,Mitamura Katsuya1,Norikane Takashi1,Nishiyama Yuka1,Hoshikawa Hiroshi1

Affiliation:

1. Kagawa University Faculty of Medicine Graduate School of Medicine: Kagawa Daigaku Igakubu Daigakuin Igakukei Kenkyuka

Abstract

Abstract Purpose: We investigated the potential of baseline 4′-[methyl-11C]-thiothymidine ([ 11C]4DST) PET for predicting loco-regional control with head and neck squamous cell carcinoma (HNSCC). Methods: A retrospective analysis was performed using volumetric parameters, such as SUVmax, proliferative tumor volume (PTV), and total legion proliferation (TLP), of pretreatment [11C]4DST PET for 91 patients with HNSCC with primary lesions in the oral cavity, hypopharynx, supraglottis, and oropharynx. As for the oropharynx, p16-negative cases were included. PTV and TLP were calculated for primary lesions and metastatic lymph nodes combined. We examined the association among the parameters and recurrence-free survival (RFS) and whether case selection focused on biological characteristics improved the accuracy of prognosis prediction. Results: The area under the curve (AUCs) using PTV and TLP for the oropharyngeal/hypopharyngeal/supraglottis groups were high (0.91 and 0.87, respectively), whereas that of SUVmax was 0.66 (p < 0.01). On the other hand, the oral group had lower AUCs for PTV and TLP at 0.72 and 0.77. When all cases were examined, the AUC values using PTV and TLP were 0.84 and 0.83, respectively. Conclusion: Baseline [11C]4DST PET/CT volume-based parameters can provide important prognostic information with p16-negative oropharyngeal, hypopharyngeal, and supraglottic cancer patients.

Publisher

Research Square Platform LLC

Reference25 articles.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray F;CA Cancer J Clin,2018

2. Jemal A, Siegel R, Ward E, Murray T. Cancer Statistics. 2007. 2007;57:43–66.

3. Robbins KT, Clayman G, Levine PA, Medina J, Sessions R. Neck Dissection Classification Update Revisions Proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch Otolaryngol Neck Surg [Internet]. 2002 [cited 2022 Apr 15];128:751–8. Available from: https://jamanetwork.com/.

4. Surgical anatomy of oropharynx and supraglottic larynx for transoral robotic surgery;Gun R;J Surg Oncol,2015

5. Whole-body distribution and brain tumor imaging with 11C-4DST: A pilot study;Toyohara J;J Nucl Med,2011

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3