Affiliation:
1. Department of Pediatric Hematology and Oncology, Hospital for Children and Adolescents, Goethe University Frankfurt
2. Department of Neuropediatrics, Hospital for Children and Adolescents, Goethe-University Frankfurt
Abstract
Abstract
Purpose
The purpose of this study was to verify whether there is a prognostic benefit of electroencephalogram (EEG) performed during initial work-up of children with newly diagnosed acute lymphoblastic leukemia (ALL)
Methods
In a retrospective monocenter study, the value of electroencephalogram (EEG) performed during initial work-up of children with newly diagnosed acute lymphoblastic leukemia (ALL) was analyzed. All pediatric patients diagnosed with de novo ALL in our institution between January 1, 2005, and December 31, 2018, in whom an EEG was performed for initial work-up within 30 days of diagnosis, were included in the study and the occurrence and etiology of seizure activity during time of cancer treatment investigated.
Results
Out of 242 children, EEG revealed pathological findings in 6 patients. Two of them developed a seizure at a later time point due to adverse effects of chemotherapy, whereas 4 children had an uneventful clinical course. In contrast, 18 patients with normal initial EEG findings developed seizures during therapy for different reasons.
Conclusion
We conclude that routine EEG does not predict seizure susceptibility in children with newly diagnosed ALL and is unnecessary in the initial work-up as EEG investigation in young and often sick children requires sleep deprivation and/or sedation, and our data demonstrate no benefit in predicting neurological complications.
Publisher
Research Square Platform LLC
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