Abstract
Background
Nocturia, a prevalent chronic condition, impacts individuals' quality of life but remains underexplored. This study aimed to assess the link between serum albumin levels and nocturia.
Methods
Analyzing NHANES data (2005–2012), 6345 adults (≥ 20 years) were studied. Nocturia was defined as ≥ 2 nocturnal voiding episodes. Logistic regression and smooth curve fitting analyzed the linear and nonlinear correlations between serum albumin and nocturia, with subgroup analysis.
Results
Among 6345 participants, 1821 (28.7%) experienced nocturia. Logistic regression analysis revealed a linear negative correlation between serum albumin and nocturia risk (OR = 0.9549, 95% CI = 0.9280 ~ 0.9827, P = 0.002). Even after quartile division of serum albumin concentration, this correlation persisted within each group, and a smooth curve fitting validated the nonlinear negative correlation between the two. Subgroup analysis further demonstrated significant impacts of BMI, alcohol consumption, and age on this association.
Conclusion
This cross-sectional study suggests a link between higher serum albumin levels and reduced nocturia risk.