Effects of Forkhead Box D1 (FOXD1) on renal cell carcinoma

Abstract

Abstract Renal cell carcinoma is a common malignancy, and the treatment is not totally effective. Studies suggest that FOXD1 may be a critical determinant of tumor biology. Our study aims to identify the key genes and signaling to find the potential targets for the FOXD1-regulated renal cell carcinoma. In our study, we analyzed the RNA-seq data of Renal cell carcinoma (RCC) with the knockout of FOXD1 and identified the transcriptional landscapes. We then introduced the gene enrichment methods including KEGG and GO to further analyze the potential signaling pathways. Additionally, we constructed the PPI network and Reactome map to further identified the biological processes. We found that the PI3K − Akt signaling pathway and MAPK signaling pathway are the major signaling pathways in the FOXD1 knockout renal carcinoma cells. We identified the top ten interactive genes including TP53, ERBB2, CXCL8, CD44, MMP9, CCL2, ICAM1, HIF1A, FGF2, and CSF2. Our study provided new insights into the mechanisms for FOXD1-regulated renal cell carcinoma.