Surgical Management of Melorheostosis Involving the Left Radius and Navicular Bone: A Case Report

Author:

Liao Zhidong1,Liu Defeng1,Chen Yifeng1,Chen Rong1,Zeng Rujiao2,Lin Zhiping1

Affiliation:

1. Guangdong Medical University

2. The Affiliated Hospital of Guangdong Medical University

Abstract

Abstract

Background: Melorheostosis is a rare chronic bone disease with a low incidence and unclear pathogenesis, often characterized by pain. It predominantly affects the long bones of the lower limbs and is often treated symptomatically and conservatively. Case presentation: A 35-year-old female presented with a three-month history of a tumor found in her left wrist joint,leading to limited mobility. There were no obvious abnormalities in laboratory tests. Physical examination indicated a palpable mass measuring approximately 1.0 × 2.0 cm in the left wrist, with limited mobility and no tenderness. Combined with Digital Radiography (DR), the patient was diagnosed with melorheostosis. Surgical intervention involving osteophyte resection was performed on the left wrist joint, resulting in a satisfactory postoperative recovery. Conclusion: The etiology of melorheostosis remains unclear, presenting with diverse symptoms that can be effectively addressed through surgical intervention.

Publisher

Research Square Platform LLC

Reference7 articles.

1. A TGF-beta-inducible cell adhesion molecule, betaig-h3, is downregulated in melorheostosis and involved in osteogenesis;Kim JE;J Cell Biochem,2000

2. Deactivating germline mutations in LEMD3 cause osteopoikilosis and Buschke-Ollendorff syndrome, but not sporadic melorheostosis;Mumm S;J Bone Min Res Off J Am Soc Bone Min Res,2007

3. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis[J]. Nature genetics;Jan H;Nat Genet,2004

4. Melorheostosis: Exome sequencing of an associated dermatosis implicates postzygotic mosaicism of mutated KRAS;Whyte MP;Bone,2017

5. A rare case of melorheostosis of the hand in a pediatric patient;Willacy RA;J Orthop,2019

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