Affiliation:
1. General Hospital Sisak
2. University Hospital Center Osijek, Josip Juraj Strossmayer University of Osijek
3. Catholic University of Croatia
Abstract
Abstract
Introduction: Vulgar psoriasis and coeliac disease are both multisystemic diseases. The association of psoriasis and enteropathy with histological changes similar to celiac disease was already described, and additionally it has been found that a gluten-free diet improves psoriatic changes.
Objectives: The objective of this study was to assess the relationship between coeliac disease antibodies and psoriasis.
Participants and Methods: The study included 112 participants, 60 with psoriasis in experimental group, and 52 healthy subjects in control group. The experimental group was subdivided in subgroup of patients with psoriasis and psoriatic arthritis (N=17), and subgroup of patients with psoriasis only (N=43). After informed consents were obtained, Dermatology Life Quality Index (DLQI) score and Psoriasis Area and Severity Index (PASI) score were evaluated. Laboratory tests included assessment of anti-deaminated gliadin peptide antibodies (anti-DGPA), anti-gliadin antibodies (anti-GA), and anti-tissue transglutaminase antibodies (anti-tTA).
Results: Positive anti-GA of immunoglobulin G (IgG) and IgA class were found more frequently and in higher serum concentrations in patients with psoriasis in comparison to healthy controls. The same was established for anti-tTA of IgG class, as well as anti-DGPA of IgA class.
Conclusion: There is relationship between positivity to coeliac disease antibodies and psoriasis, in particular concerning antigliadin antibodies. Further studies are necessary to determine the nature, pathophysiology, and the meaning of these findings.
Publisher
Research Square Platform LLC
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