Abstract
The treatment of hepatic malignant tumors poses a significant global health challenge, often managed through percutaneous microwave ablation (MWA). Understanding the effectiveness of MWA and the factors influencing tumor recurrence is essential for improving patient outcomes. Methods: In this study, a cohort of 101 patients out of 249 with hepatic malignant tumors treated at the Shandong Cancer Hospital and Institute were analyzed. The study evaluated disease-free and overall survival rates at 1, 2, and 3 years post-MWA, exploring correlations between tumor recurrence and variables such as Child-Pugh B liver function classification and lesion count. Additionally, a meta-analysis was conducted to identify independent risk factors for recurrence following MWA treatment. Results: Disease-free survival rates of 80.2%, 72.3%, and 70.3% at 1, 2, and 3 years post-MWA were observed, alongside overall survival rates of 99%, 97%, and 96%. Noteworthy associations were found between tumor recurrence and Child-Pugh B classification, as well as the number of lesions. The meta-analysis further supported lesion count and Child-Pugh B classification as independent risk factors for recurrence post-MWA. Conclusion: Child-Pugh B classification and lesion count emerge as pivotal factors in predicting tumor recurrence post-MWA treatment for hepatic malignant tumors. These insights offer valuable guidance to clinicians in treatment decisions and post-treatment monitoring strategies, potentially leading to improved patient care and outcomes.