Abstract
Abstract
The first, second, third, and fourth-order derivative spectrophotometric methods by using the peak—zero (P - O) and peak-peak (P - P) techniques of measurement have been developed for the determination of levofloxacin, norfloxacin, and moxifloxacin in their combined pharmaceutical dosage form or individually for levofloxacin, norfloxacin, and moxifloxacin. Linearity was achieved at 2–20 µg/ml. The procedure is Simple, quick, and precise. The developed method is sensitive and precise. simple, accurate, and cost-effective, and exhibited a good correlation coefficient (R2 = 0.9998) and excellent mean recovery (99.20–100.08%), indicating a high degree of precision of the methods. This approach was successfully used to determine the levofloxacin, norfloxacin, and moxifloxacin content in marketed pharmaceutical dosages. The method's linearity, and accuracy, were confirmed statistically and through recovery tests. The results showed that the method can be used for routine analysis in bulk and commercial formulations.
Publisher
Research Square Platform LLC
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