The correlation between Framingham risk score and hypertension combined with hyperuricemia in an elderly community-based population--a 7-year cohort follow-up study

Abstract

Abstract Background Research has consistently demonstrated a robust association between hypertension (HTN) and hyperuricemia (HUA), indicating a potential synergistic effect on cardiovascular disease (CVD) risk. This study aims to explore the epidemiological characteristics of hypertension combined with hyperuricemia (HTN-HUA) and to identify the risk factors contributing to its incidence. Methods This study was a cohort follow-up, utilizing a community-based cohort consisting of older adults aged 65 years or older. Initially, the study enrolled 3,950 participants in a prospective manner. After the exclusion of cases with missing data, the analysis ultimately included 3,089 participants. We employed the Framingham Risk Score (FRS) formula to estimate the risk of CVD. Survival analysis was conducted to explore the relationship between FRS and CVD death/all-cause mortality. Furthermore, multiple logistic regression models were utilized to assess the association between FRS and HTN-HUA. Results Within the study population, we found that approximately 29.6% of hypertensive patients were also suffering from HUA. We observed that regardless of the presence of HTN or HUA, age, WC, SBP, DBP, Scr, and UA levels were significantly higher in the High-risk group than in the L-M risk group (P < 0.05). The Kaplan-Meier survival analysis, which used CVD death as the endpoint, revealed a significant difference in survival curves between the High-risk and low-intermediate (L-M) risk groups among relatively healthy individuals (P < 0.01). Furthermore, following adjustments for confounding variables, logistic regression analysis revealed that the risk of HTN-HUA in the High-risk group was 1.485 times greater than in the L-M risk group (OR = 1.485, 95% CI: 1.092–2.021). Conclusion In a community-based elderly population in China, the prevalence of HTN-HUA was found to be 17.5%. The FRS effectively predicted a 10-year cardiovascular risk in a relatively healthy population. Additionally, waist circumference (WC) and body mass index (BMI) were identified as significant risk factors for the development of HTN-HUA.