Abstract
Introduction
Green synthesis is the production of metal nanoparticles (MNPs) with biological agents, including plant extracts, without special physical and chemical solutions and conditions. Due to their unique properties, MNPs are used in various sciences and industries. The study aimed to investigate the cytotoxic effects of zinc nanoparticles (ZnNPs) synthesized by the hydroalcoholic extract of lavender plant against human breast cancer cell lines (MCF7) and human colon cancer cell lines (HT29) with the approach of identifying the ability of these NPs to produce anticancer drugs.
Method and Materials:
ZnNPs are synthesized using the hydroalcoholic extract of the lavender plant. Evaluate and characterize nanoparticles (NPs) by Tyndall effect, UV-Vis, DLS, FT-IR, Zeta-P, Raman spectroscopy, SEM, AFM, and XRD methods. The cytotoxic effects of produced NPs against cancer cell lines MCF7 and HT29 and the healthy cells MCF10a and HGF were measured using the MTT method.
Results:
According to the findings of DLS analysis, the average size of ZnNPs is 40 and 50, respectively, at a concentration of 3 mM. The cytotoxicity of nanoparticles on MCF7 and HT29 cell lines produces the highest effect after 48 hours.
Conclusion:
The lavender plant is a suitable option for the green synthesis of ZnNPs and can be used as a stable source for production MNPs. Also, the synthesized ZnNPs showed cytotoxic effects against the examined cancer cells, while they did not cause toxicity to healthy human cells.