Relationship Between Ki-67 And Breast Cancer A historical cohort study

Abstract

Abstract purpose According to past studies and the importance of Ki-67 in breast cancer, a clear cut-off point for prognosis and prediction of recurrence has not yet been determined; Therefore, the purpose of this study is to investigate the level of Ki-67 in breast cancer patients and its relationship with other laboratory markers and clinical findings, and finally its relationship with patient survival. Methods Patient information was extracted from their medical records. patients in stages Ⅱ and Ⅲ who underwent a mastectomy, chemotherapy, radiation, and hormone therapy were included in the study, and patients with incomplete information were excluded. According to the Ki-67 level, patients were divided into three groups and followed up for 36 months. Results According to the inclusion and exclusion criteria, 500 patients were included in the study. Ki-67 level had a significant relationship with disease stage (p = 0.037), tumor size (p = 0.006), estrogen (p < 0.001), and progesterone (p < 0.001) receptors, HER2 (p < 0.001) and molecular subgroups (p < 0.001), as well as with disease-free interval (DFI) (p < 0.001), but it had no significant relationship with patients' age and lymph nodes. In examining the relationship between Ki-67 level and disease-free interval in each molecular subgroup, there was a significant relationship only in luminal A (p = 0.003) and luminal B (p = 0.004) subgroups, and it was not significant in HER2-enrich and triple-negative subgroups. Conclusion Ki-67 can be useful in predicting recurrence, especially in patients in luminal A and luminal B molecular subgroups.