Regulation of LARP4 in malignant biological behavior of GBM

Abstract

AbstractBackground Glioblastoma (GBM) is the most prevalent form of primary brain cancer. La-related protein 4 (LARP4) is known to play a crucial role in various types of cancer. Nevertheless, the expression and function of LARP4 in GBM have not been thoroughly investigated. Methods The TCGA database was utilized to analyze the expression level of LARP4 in GBM. The relationship between LARP4 and immune infiltration levels was investigated using TIMER. Furthermore, the knockdown of LARP4 lentivirus was constructed and transfected into GBM cells to evaluate its impact on cell migration and invasion via functional assays. Results The study found that LARP4 expression in GBM was significantly higher and associated with a lower survival rate in patients with the disease. Knockdown of LARP4 inhibited cell proliferation and horizontal migration while promoting early apoptosis in GBM cells. In addition, the expression level of LARP4 also had a positive correlation with CD8 + T cells, macrophages, and neutrophils in GBM. Conclusion These results suggest that LARP4 could be a potential new molecular target for glioma in a clinical setting.