Efficacy and safety of fecal microbiota transplantation in the treatment of ulcerative colitis: a systematic review and meta-analysis

Author:

Feng Jing1,Chen Yexin2,Liu Yan3,Lin Lin4,Lin Xiujuan4,Gong Wenxiu4,Xia Rongmu4,He Jianquan2,Sheng Jianwen5,Cai Huimei6,Xiao Chuanxing2

Affiliation:

1. Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University

2. Fujian University of Traditional Chinese Medicine

3. Chongqing General Hospital

4. Xiamen Treatgut Biotechnology Co., Ltd

5. The Affiliated Hospital of Yichun University

6. Fuzhou First Hospital affiliated to Fujian Medical University

Abstract

Abstract Purpose To explore the efficacy and safety of fecal microbiota transplantation (FMT) as a treatment approach for ulcerative colitis (UC), a comprehensive systematic review and meta-analysis of randomized controlled trials was conducted. Methods To collect and evaluate randomized controlled trials of high quality on FMT for UC, we searched a number of databases, including PubMed, Web of Science, Cochrane, Embase, and Medline, for studies published between the establishment of the databases and March 2023. We conducted a meta-analysis of the studies using Review Manager software (version 5.4.1) to determine the differences in rates of remission and adverse reactions between the FMT group and the control group, utilizing the risk ratio (RR) and 95% confidence interval (CI) to combine our findings. Results A total of 13 RCTs on the efficacy of FMT in patients with UC were included in the study, in which 580 patients participated, including 293 patients treated with FMT and 287 control subjects. Meta-analysis revealed that clinical remission was significantly better in the FMT group than in the control group [RR = 1.73; 95% CI = (1.41, 2.12); P < 0.00001]; endoscopic remission was significantly better in the FMT group than in the control group [RR = 1.74; 95% CI = (1.24, 2.44); P = 0.001]. Additionally, there were no significant differences in the incidence of adverse reactions between the two groups [RR = 1.00; 95% CI = (0.86, 1.15); P = 0.96]. Conclusions FMT is an effective treatment for UC with good clinical remission rates and endoscopic remission rates. However, safety remains a concern during treatment and measures must be taken to enhance both safety and success rates.

Publisher

Research Square Platform LLC

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