Predictors of Neonatal Hyperbilirubinemia's Outcome and Their Relationships to the Etiology.

Abstract

Abstract Background Neonatal jaundice (NJ) accounts for 13.5% of all neonatal care unit admission, making it the third common cause of admission for neonates. Although jaundice is a benign condition, newborn should be assessed in order to prevent further progression into severe hyperbilirubinemia and acute encephalopathy. So, we aimed in this study to assess neonatal hyperbilirubinemia etiologies, outcomes, and the predictors of these outcomes in Minia Governorate, Egypt. Methods It was a prospective study included one hundred sixty nine neonates with clinical jaundice who were admitted in Neonatal Intensive Care Unit in Minia university children hospital during the period from August 2022 to May 2023. They randomly selected and were subjected to; a structured questioner, clinical examination and laboratory investigations. They were followed up to detect their outcomes (survival, mortality or discharged with complications. Results most common cause is exaggerated physiological jaundice (40.8%) followed by ABO incompatibility (25.4%), RH incompatibility (16.6%), sepsis (8.9%) and G6PD deficiency (%8.3).Neonates with exaggerated physiological jaundice were statistically significant recovered more than those with other causes. Neonates with sepsis had poor outcome. Bilirubin level at admission was a significant predictor for the good outcome (survival) of neonatal hyperbilirubinemia. Conclusion Weight, prematurity, history of previous jaundiced baby, breast feeding, bilirubin level at admission and CRP were significantly related to the outcome of jaundice.