The Potential Protective Effect of Spirulina Nanoparticles Against Ehrlich Solid Tumor Bearing Mice Induced Liver Toxicity, Tumor Markers, DNA Fragmentation, Oxidative Stress and Monooxygenase Variations

Abstract

Abstract Ehrlich solid tumor (EST) is a spontaneous murine mammary adenocarcinoma, undifferentiated, making mainly beneficial for tumors studies. The current research aim to describe the antineoplastic activity of spirulina nanoparticles extract (SP NPs) against EST induced alteration in liver functions, oxidative stress, tumor markers, monooxygenase and DNA damage in female mice. 40 female mice were arbitrarily doled out into 4 gatherings (1st, Control; 2nd, SP NPs; 3rd, EST; 4th, EST + SP NPs). Results revealed significant elevation in the levels of AST, ALT, GGT, ALP, AFP, CEA, DNA damage; thiobarbituric acid reactive substances (TBARS), and glutathione peroxidase (GPx) in liver homogenate and depletions in the levels of albumin, total proteins, cytochromes (CYP450 & cyt b5), reduced glutathione (GSH), glutathione reductase (GR), glutathione S transferase (GST) and superoxide dismutase (SOD) activity in liver homogenate compared to control. EST Treatment with SP NPs (EST + SP NPs) improved and modulates these variations in liver functions, tumor markers, DNA damage, cytochromes, enzymatic and non-enzymatic, and oxidative stress as compared to mice bearing EST. These results suggest that SP NPs may have hepatic protective, antioxidant, and anti-cancer properties; in addition to inhibition of the EST development, and liver DNA damage induced by EST.