Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.-Reference-Cited by-同舟云学术

Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.

Published:2024-01-10 Issue: Volume: Page:
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Author:

Keser Engin¹^ORCID,Liao Wangjingyi²,Allegrini Andrea³^ORCID,Rimfeld Kaili⁴,Eley Thalia⁵^ORCID,Plomin Robert⁶^ORCID,Malanchini Margherita²^ORCID

Affiliation:

1. King's College London

2. Queen Mary University of London

3. University College London

4. Royal Holloway, University of London

5. Kings College London

6. Institute of Psychiatry, Psychology and Neuroscience, King's College London, London

Abstract

Abstract Evidence indicates a great degree of genetic overlap between psychiatric diagnoses. Accounting for these transdiagnostic effects can sharpen research on disorder-specific genetic architecture. Here we isolate genetic effects that are shared across 11 major psychiatric disorders (p factor) to gain further insight into genetic specificity and comorbidity over and above that contributed by the p factor, unique to each psychiatric disorder. After adjusting for transdiagnostic genetic effects, we identified novel SNP associations and some changes in enrichment patterns. We examined genetic correlations among adjusted psychiatric traits as well as relationships with other biobehavioural traits. The landscape of genetic associations between pairs of psychiatric disorders changed substantially, and their genetic correlations with biobehavioural traits showed greater specificity. Isolating transdiagnostic genetic effects across major psychiatric disorders provides a nuanced understanding of disorder-specific genetic architecture and may help guide diagnostic nomenclature and treatment research.

Publisher

Research Square Platform LLC

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