XRCC1 gene rs72484243 polymorphism is associated with increased laryngeal cancer risk

Abstract

Abstract Background The focus of this research is to discuss whether genetic polymorphisms in the DNA repair gene XRCC1 are linked to laryngeal cancer in patients. Methods In total 120 individuals, comprising 60 patients with Laryngeal squamous cell carcinoma (LSCC) and 60 healthy volunteers, participated in the present research. Blood samples were taken and analyzed and four XRCC1 polymorphisms (rs145135970, rs1799780, rs25489, and rs72484243) were genotyped. Results Sex, age, BMI, and smoking were shown to be the high-risk factors in the LSCC populations. Genotype and allele distributions for rs145135970, rs1799780, rs25489, and rs72484243 differed significantly between LSCC and control groups (all P < 0.05). Furthermore, carriers with the rs72484243 GTGT- allele exhibited an increased risk of LSCC relative to those who had the rs145135970 GTGTGTGTGTGTGT- allele, the rs1799780 G-A allele, or the rs25489 C-T allele, as determined by binary logistic regression analysis (OR = 2.74, 95% CI: 1.27–5.91, P = 0.01), after accounting for possible confounders like sex, age, BMI, drinking and smoking behavior, and special diet requirements. In addition, a TA haplotype and a GTGTGTGTGTGTGTTG haplotype were linked to LSCC in Chinese populations in a haploid association study of four SNP loci in the XRCC1 gene (P = 0.05; OR = 1.36, 95% CI = 1.1228–1.6406). Conclusions A large-scale population-based investigation is strongly recommended since rs72484243 gene variations are linked to an elevated risk of LSCC.