Changes in clinicopathological characteristics and surgical methods of adrenal tumors: high-volume institution experience of 1358 cases

Abstract

Abstract Background: The aim of this study to investigate the change trends in clinicopathological characteristics and surgical methods of adrenal tumors(AT) at a high-volume institution experience. Methods: Data of AT patients who underwent adrenalectomy at our institution from January 2012 and December 2021 were retrospectively evaluated. The change trends of age, gender, nationality, tumor side, clinical manifestations, endocrine type,tumor diameter,pathological types and surgical methods indicators were analyzed between the two stages. Result: A total of 1358 patients (mean age 46.2 years and diameter 3.38 cm) with underwent adrenalectomy were identified. There were 793 females and 565 males. Nationality include 905 han, 404 zhuang and 49 the other nationalities. There were 714 left side, 625 right side and 19 bilateral sides. Clinical manifestation included 914 clinical and 444 incidental types. Endocrine types included 729 function and 629 non-function.Histopathological diagnosiss included 1315 benign tumors (508 non-function adenomas, 298 primary aldosteronism, 215 pheochromocytomas,88 Cushing syndrome, 62 cyst,55 non-function nodular hyperplasia and 89 the other tumors) and 43 malignancies (17 adrenocortical cancer,9 metasta­sis and 17 the other tumors). The sum of the surgical types included 1059 RPLA,145 TPLA,106 OA and 48 RALA. Conclusions: In our institution,there were more females than males.Simultaneously, Han were more than Zhuang nationalities. AT tended to occur on the left side, predominant clinical and functional types. Non-functional adenomas and ACC were the main pathological types of benign and malignant tumors, respectively. Although there were various surgical types for AT, RPLA was still the main surgical methods in our center. Keywords: Adrenal tumors, Clinicopathological characteristics, Surgical methods, Change trends