Comparative Efficacy Evaluation of 10% Sodium Iodide and Potassium Iodide Therapies of Horses With Eipizootic Lymphangitis at Spana Equine Clinic, Bishoftu, Ethiopia

Abstract

Abstract Purpose To identify the comparative effectiveness of different drug combinations and routes of drug administration for epizootic lymphangitis in horses in Bishoftu town, Ethiopia. Methods Experimental study was conducted on forty horses with Epizootic lymphangitis. After identification of cases and oral consent from horse’s owner the study were conducted. Selected horses were examined and attributed an EZL in six grading level depending on the severity of the disease. The study was conducted in five different experimental groups in which equal numbers of eight experimental units were assigned. Results The presence of EZL was confirmed in a total of forty horses by Giemsa stain. Animals were then included in the trial to assess the comparative effectiveness of different treatment protocols. The analysis of variables of all experimental groups and all variables of the study group (number of nodules, number of discharging nodules, recovered nodules and grade) shows statistical significant (P < 0.05) differences. All experimental units were examined six times with 48 frequencies. Grade was mostly preferred to determine the level of effectiveness of the drug. The statistically significant differences in therapeutic value were observed by pairwise comparison of all groups. The oral KI in combination with topical 4% iodine tincture versus 10% NaI IVRP in combination with topical 4% iodine tincture, 10% NaI through jugular vein in combination with topical 4% iodine tincture and debridement and topical 4% iodine tincture with their respective P values were 0.004, 0.025 and 0.018. Conclusion The combination of 10% NaI through jugular vein in combination with topical application of 4% iodine tincture was comparably better effective treatment than other remedies. Most of the horse owners also responded that intravenous injection of the drugs in combination with 4% iodine tincture topically had better therapeutic value than other remedies.