Increased segmented neutrophils and red cell distribution width level in peripheral blood is highly correlated with prevalent tooth loss

Abstract

Abstract Background Tooth loss is a common oral health problem that can significantly impact an individual's quality of life. Despite a general decrease in severe tooth loss, it remains prevalent globally and can be caused by multiple factors, including chronic inflammation and systemic diseases such as diabetes and cardiovascular disease. To investigate the relationship between peripheral blood indices and tooth loss by analyzing data from the National Health and Nutrition Examination Survey (NHANES) and uncover any potential clinical biomarkers in peripheral blood for tooth loss. Methods This study analyzed data from the NHANES collected from 2017 to March 2020. Age, gender, race, C-reactive protein, and complete blood count were employed as variables. Multivariate logistic regression models to examine the association between the important variables and tooth loss. Odds ratios (OR) with 95% confidence intervals (95%CI) was used to evaluate the significance of association. Results A total of 9094 participants were finally included in the trial. In peripheral blood, tooth loss was highly linked with higher levels of segmented neutrophils (OR = 1.12; 95% CI: 1.05–1.20; p = 0.0017) and red cell distribution width (OR = 1.12, 95% CI: 1.07–1.16; p < 0.001). The degree of the connection between these factors and tooth loss varied by age, gender, and ethnicity, as shown by subgroup analysis. Conclusions The results suggest that higher segmented neutrophils and red cell distribution width levels in peripheral blood may be associated with a higher risk of tooth loss and could serve as risk markers for tooth loss.