Autocatalytic reaction cycles for non-enzymatic synthesis of life-sustaining sugars in neutral media-Reference-Cited by-同舟云学术

Autocatalytic reaction cycles for non-enzymatic synthesis of life-sustaining sugars in neutral media

Published:2022-09-06 Issue: Volume: Page:
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Author:

Tabata Hiro¹^ORCID,Chikatani Genta¹,Nishijima Hiroaki¹,Harada Takashi¹^ORCID,Miyake Rika¹,Kato Souichiro²^ORCID,Igarashi Kensuke³^ORCID,Mukouyama Yoshiharu⁴^ORCID,Shirai Soichi⁵^ORCID,Waki Minoru⁵^ORCID,Hase Yoko⁶^ORCID,Nakanishi Shuji⁷^ORCID

Affiliation:

1. Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan

2. Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1, Tsukisamu higashi, Toyohira, Sapporo 062-8517, Japan

3. Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1, Tsukisamu higashi, Toyohira, Sapporo 062-8517, Japan

4. Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan; Division of Science, College of Science and Engineering, Tokyo Denki University, Ishizaka, Hatoyama, Hiki, Saitama 350-0394, Japan

5. Toyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi 480-1192, Japan

6. Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan; Toyota Central R&D Labs., Inc., 41-1 Yokomichi, Nagakute, Aichi 480-1192, Japan

7. Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan; Innovative Catalysis Science Division, Institute for Open and Transdisciplinary Research Initiatives (ICS-OTRI), Osaka University, Suita, Osaka 565-0871, Japan

Abstract

Abstract Biological assimilation of CO2 to produce sugars occurs in metabolic cycles with an autocatalytic nature, such as the Calvin cycle and reverse citric acid cycle. The formose reaction, in which sugars are non-enzymatically synthesized from formaldehyde under basic conditions, involves such an autocatalytic cycle and has attracted much interest from the viewpoint of the abiotic chemical synthesis of sugars. However, many side reactions are indiscriminately accelerated by hydroxide ions, which results in a very low selectivity of sugar formation. Here we report non-enzymatic sugar synthesis under neutral conditions using mono-oxometalate as a catalyst to form an autocatalytic cycle. The construction of an autocatalytic reaction system under neutral conditions significantly improved the selectivity of sugar formation. It was also demonstrated that abiotically synthesized sugars could sustain the growth of microbial cells.

Publisher

Research Square Platform LLC

Reference48 articles.

1. The compositional and evolutionary logic of metabolism;Braakman R;Physical biology,2013

2. Autocatalytic sets in E. coli metabolism;Sousa FL;Journal of Systems Chemistry,2015

3. Chemical Basis of Carbon Fixation Autotrophic Paleometabolism;Marakushev SA;Biology Bulletin,2021

4. Bildung einer zuckerartigen Substanz durch Synthese;Butlerow A;Annalen der Chemie und Pharmacie

5. On the mechanism of the formose reaction;Breslow R;Tetrahedron Letters,1959