Unveiling the Axonal Connectivity Between the Precuneus and Temporal Pole: Structural Evidence from the Cingulum Pathways

Abstract

Abstract Neuroimaging studies have consistently demonstrated concurrent activation of the human precuneus and temporal pole, both during resting-state conditions and various higher-order cognitive functions. However, the precise underlying structural connectivity between these brain regions remains uncertain despite significant advancements in neuroscience research. In this study, we investigated the connectivity of the precuneus and temporal pole by employing parcellation-based fiber micro-dissections in human brains and fiber tractography techniques in a sample of 1,065 human subjects and a sample of 41 rhesus macaques. Our results demonstrate the connectivity between the posterior precuneus area POS2 and the areas 35, 36, TG, and TI of the temporal pole via the fifth subcomponent of the cingulum (CB-V) also known as parahippocampal cingulum. This finding contributes to our understanding of the connections within the posteromedial cortices, facilitating a more comprehensive integration of anatomy and function in both normal and pathological brain processes.