Affiliation:
1. Chongqing Medical University
2. The First Affiliated Hospital of Chongqing Medical University
3. Southwest Medical University
Abstract
Abstract
Low-grade gliomas (LGG) are a group of heterogeneous brain tumors that originate from glial cells, and lack effective biomarkers for diagnosis and predicting prognosis. In this study, we found that both transcriptional and protein levels of TBC1 domain family member 1 (TBC1D1) are significantly increased in tumors, and indicated poor prognosis of LGG patients. In addition, the nomogram constructed based on TBC1D1 showed that TBC1D1 exerted satisfactory performance in predicting the survival probability of LGG patients. Notably, high TBC1D1 expression in M2-like pro-tumor macrophages is closely correlated with the immunosuppressive microenvironment of the glioma. Collectively, these findings support that high TBC1D1 expression indicate immunosuppressive microenvironment and predicted poor prognosis in LGG patients.
Publisher
Research Square Platform LLC