Solid Dispersions as a Tool to Enhance Solubility of Chlorzoxazone

Abstract

Abstract Chlorzoxazone belongs to BCS class II with prominent diminished solubility. The drug owing to low solubility has a marked poor bioavailaibility as maximum of it is rendered to the metabolism by CYP2E1 enzyme in the liver. The main purpose of the work is to enhance the solubility of the drug through the formulation of solid dispersions. Various methods like Co-grinding, Co-precipitation, Fusion method, and Closed melting method were used to formulate the Solid Dispersions. The Solid Dispersions were characterized for in-vitro drug release for F1(Fusion 1),F2 (Fusion 2) C1 (Closed Melting 1),C2 (Closed Melting 2),Co-P (Co-precipitation),Co-G (Co-grinding). Based on drug release profile and solubility studies the formulation made by the F2(Fusion method) with the drug, polymer ratio (0.5:1.0) was obtained with bestresu;ts among all. The results showed that the dispersions has a negligible interation in transformation from crystalline to amorphous state.