Affiliation:
1. Thoraxklinik University of Heidelberg
2. Heidelberg University
3. University Hospital Heidelberg
4. Asklepios Hospital Barmbek, Pneumology and Internal Intensive Care Medicine
5. aQua Institute for Applied Quality Improvement and Research in Health Care
6. SLK-Klinik Löwenstein
7. Robert-Bosch-Krankenhaus Klinik Schillerhöhe
8. Wangen im Allgäu
Abstract
Abstract
Background
Invasive mechanical ventilation (IMV) is a standard therapy for intensive care patients with respiratory failure. With increasing age and multimorbidity the number of patients rises, who cannot be weaned from IMV, leading to impaired quality of life and high costs. In addition, human resources are tied up in the care of those patients.
Methods
The PRiVENT intervention is a prospective, mixed-methods interventional, multicentre study with a parallel comparison group selected from insurance claims data of the health insurer Allgemeine Ortskrankenkasse Baden-Württemberg (AOK-BW) conducted in Baden-Württemberg, Germany, over 24 months. Four weaning centres supervise 40 intensive care units (ICUs), that are responsible for patient recruitment. The primary outcome, successful weaning from IMV, will be evaluated using a mixed logistic regression model. Secondary outcomes will be evaluated using mixed regression models.
Discussion
The overall objective of the PRiVENT project is the evaluation of strategies to prevent long-term IMV. Additional objectives aim to improve weaning expertise in and cooperation with the adjacent Intensive Care Units.
Trial registration number:
This study is registered at ClinicalTrials.gov (NCT05260853).
Publisher
Research Square Platform LLC