A Conducting Polymer-based array with Multiplex Sensing and Drug Delivery Capabilities for Smart Bandages

Abstract

Abstract Effective individual wound management, particularly in cases of prolonged healing and increased infection vulnerability, has prompted the development of wound theranostics, combining real-time diagnostic assessment and on-demand treatment. We present a multifunctional conducting polymer-based smart theranostic bandage platform that integrates pH sensing, pH-compensated uric acid (UA) biosensing, and on-demand antibiotic release using different conducting polymers, each leveraging their advantageous intrinsic properties. Specifically, the polyaniline-based pH sensor operates reversibly across a broad pH range (4–10), while the functionalized poly(3,4-ethylenedioxythiophene)-based UA biosensor exhibits a linear response up to 0.9 mM UA. Simultaneous detection of pH and UA allows accurate UA determination via pH compensation. Upon detecting abnormal pH/UA levels, the polypyrrole-based drug carrier releases ciprofloxacin via an electrical stimulation (0.6 V), successfully inhibiting bacterial growth in vitro. The array is assembled as a 3D patch, connected to a flexible printed circuit board, and embedded in a wound bandage, offering potentials for remote wound monitoring, targeted treatment, and wireless wound management.