The assessment of leukocyte systemic inflammation index ratios in dyslipidemia patients with dry eye disease

Abstract

Abstract Background One of the many adverse effects of dyslipidemia (DLP) is dry eye disease (DED), which is brought on by metabolic syndrome and increases inflammation. This research aimed to assess the leukocyte systemic inflammation index ratios in DLP with DED (DED-DLP) as potential biomarkers of systemic inflammation. Methods Several sets of blood biomarkers were studied. There were specific leukocyte profile parameters (neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), and neutrophil-to-lymphocyte*platelet ratio (NLPR)); the lipid profile (levels of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein and triglycerides): and an inflammation marker (C-reactive protein (CRP)). These were evaluated in 32 patients with DED-DLP (study group) and 52 subjects without DLP (control group). Results The study group had significantly greater levels of monocytes and CRP than did the control group (p = 0.024 and 0.049, respectively). A negative correlation with a statistically significant difference between HDL and NLPR (p = 0.007; r=-0.428) and a negative correlation with a statistically significant difference between albumin levels and PLR values (p = 0.008; r=-0.420) were seen as predictors of DED-DLP. Conclusion Individuals with DLP are more likely than those without the condition to experience DED because the levels of their leukocyte systemic inflammation index ratios reflect the seriousness of systemic inflammation. The study found that CRP and NLPR levels might be helpful as predictors of the likelihood of the development of DED by DLP patients. Additional research is needed to determine the additive contribution played by leukocytes and the significance of NLR, PLR, and MLR.