Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Author:

Liu Xiaoqiang1,Huang Yisen1,Huang Yingxuan1,Lin Chanchan1,Xu Boming1,Zeng Yilin1,Chen Peizhong1,Liu Xiaobo2,Wang Yubin1

Affiliation:

1. First Hospital of Quanzhou Affiliated to Fujian Medical University

2. McGill University

Abstract

Abstract

Background Trouble sleeping is prevalent in modern society and is known to be associated with various health problems. However, studies on the relationship between trouble sleeping and gallstones are relatively few. This study aims to explore the potential association between trouble sleeping and gallstones among adult Americans. Methods Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were analyzed, including 7,438 adult participants. The relationship between trouble sleeping and gallstones was assessed using multivariable logistic regression models, with sensitivity analyses performed using multiple imputation, weighted analysis, and propensity score matching. Results Among the 7,438 participants, 780 (10.5%) reported having gallstones. The analysis showed a significantly increased risk of gallstones among participants with trouble sleeping (adjusted odds ratio [AOR] = 1.49, 95% confidence interval [CI] = 1.26–1.76, P < 0.001). Subgroup analyses indicated consistent associations across different subgroups based on sex, age, obesity, diabetes, and hypertension, with interaction observed in age subgroups. Conclusion The findings suggest that trouble sleeping may be an independent risk factor for gallstones. This highlights the potential importance of improving sleep quality in the prevention of gallstones.

Publisher

Springer Science and Business Media LLC

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