Affiliation:
1. Western University
2. McMaster University, Hamilton, Canada
3. Lawson Health Research Institute
4. McMaster University
Abstract
Abstract
The dissociative subtype of post-traumatic stress disorder (PTSD) is a distinct PTSD phenotype characterized by trauma-related dissociation, alongside unique patterns of small and large-scale functional connectivity. However, disparate findings across these various scales of investigation have highlighted the need for a cohesive understanding of dissociative neurobiology. We took a step towards this goal by conducting the largest region of interest (ROI)-to-ROI analysis performed on a PTSD population to date. While modest functional connectivity differences were found between participants with PTSD and controls in the temporal regions and the right frontoparietal network, participants with the dissociative subtype demonstrated a markedly different pattern of widespread functional hyperconnectivity among subcortical regions, sensorimotor-related networks, and other intrinsic connectivity networks, when compared to controls. Furthermore, joint brain-behavior factor analysis identified two dissociative and one PTSD symptom-linked factor. These results advance our understanding of dissociative neurobiology, characterizing it as a divergence from normative small-world organization.
Publisher
Research Square Platform LLC
Reference84 articles.
1. The dissociative subtype of posttraumatic stress disorder: Rationale, clinical and neurobiological evidence, and implications;Lanius RA;Depress Anxiety,2012
2. A latent class analysis of dissociation and posttraumatic stress disorder: Evidence for a dissociative subtype;Wolf EJ;Arch Gen Psychiatry,2012
3. Aiding the diagnosis of dissociative identity disorder: pattern recognition study of brain biomarkers;Reinders AATS;BJPsych,2019
4. Biomarkers of pathological dissociation: A systematic review;Roydeva MI;Neurosci Biobehav Rev,2021
5. A multidimensional meta-analysis of psychotherapy for PTSD;Bradley R;Am Journal Psychiatry,2005
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献