Management of gout in primary care of Hong Kong in accordance with international guidelines: any gaps to bridge?

Author:

Chan Kamsheung1,Chen Catherine Xiaorui1,Chiang Lapkin1,Ho Kaming1,Li Yimchu1

Affiliation:

1. Queen Elizabeth Hospital

Abstract

Abstract

Background Gout is one of the most common conditions encountered in primary care. This study aims to assess urate control among gout patients managed in primary care settings and to evaluate its associated risk factors. Method Retrospective cross-sectional study. All adult Chinese gout patients who had been followed up in public primary care clinics from 1 January 2021 to 31 December 2021 were included. Patient demographics, clinical and biochemical parameters were retrieved from the computer system. Student’s t-test was used for analyzing continuous variables and Chi-square test was used for categorical data. Multivariate stepwise logistic regression was used to determine the associated risk factors for poor urate control. Results Among the 385 gout patients included, 115 met the target serum urate level (29.9%). All patients with tophaceous gout could not achieve the target serum urate level. In multivariate studies, male gender (OR 2.587, 95% CI: 1.374–4.873), active smoker (OR 3.170, 95% CI: 1.077–9.333), Chronic kidney disease with stage 3a, 3b and 4, (OR 3.236, 3.122 and 10.250 respectively, 95% CI: 1.556–6.732, 1.113–8.758 and 1.078–97.477 respectively) were less likely to meet the target urate level while those on urate-lowering agents (OR 0.225, 95% CI: 0.0.127–0.399) were more likely to meet the target urate level. Conclusion Only 29.9% of gout patients were adequately treated in public primary care settings in Hong Kong. Tophaceous gouty patients are found to have difficulties in achieving target serum urate level. Gout patients who were male, active smokers, having Chronic kidney disease with stage 3a, 3b and 4 were less likely to meet the target urate level while those on urate-lowering agents were more likely to meet the target urate level.

Publisher

Springer Science and Business Media LLC

Reference20 articles.

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2. Tommy Tsang Cheung. Epidemiology of gout in Hong Kong: a population-based study from 2006 to 2016;Tsoi MF;Arthritis Res Therapy,2020

3. Tophaceous gout and high level of hyperuricemia are both associated with increased risk of mortality in patients with gout;Perez-Ruiz F;Annals Rheumatic Dis [Internet],2014

4. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective;Yu W;Front Pharmacol,2020

5. 2016 updated EULAR evidence-based recommendations for the management of gout;Richette P;Ann Rheum Dis,2017

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