Peripheral blood circulating tumor cells and glycan antigen 153 as biomarkers for diagnosis and prediction of prognosis in breast cancer: a retrospective study

Abstract

Abstract Background Our aim was to study the diagnostic and prognostic value of circulating tumor cells (CTC) and glycan antigen 153 (CA153) expression in breast cancer patients. Methods 171 breast cancer patients were collected as an observation group, and another 126 cases of benign breast lesions in the same period were selected as a control group, to analyze the difference and correlation between the expression of CA153 and CTC in the two groups, and to compare the diagnostic value of CA153, CTC, and the combined detection for breast cancer. Finally, CTC expression was analyzed in relation to different clinicopathological parameters of breast cancer and CA153. Results The CTC positivity rate and CA153 expression level of the observation group were significantly higher than those of the control group, and Point-biserial analysis showed that there was a positive correlation between CTC and CA153 (r = 0.53,P༜0.01); the combined detection of CTC and CA153 had a higher sensitivity than that of the independent detection, and a lower specificity than that of the independent detection, and the combined detection of Youden's-index, Kappa-index, and Kappa-index was more effective in diagnosing breast cancer. index) and Kappa value were the highest at 0.8 and 0.79, respectively, which had higher diagnostic value; CTC expression was related to choroidal infiltration, TNM staging, and CA153 expression (P ༜0.05). Conclusions The expression of CA153 and CTC in breast cancer was significantly elevated and correlated, and the combined detection of the two had a higher diagnostic value for breast cancer, and CTC detection predicted the prognosis of breast cancer.