Morbidity and Mortality of Patients With Peritoneal Malignancy Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Intraoperative Chemotherapy

Abstract

Abstract Background The purpose of this study was to record the incidence, and identify the prognostic variables of morbidity and mortality in patients with peritoneal malignancy undergoing cytoreductive surgery (CRS) combined with hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC).Methods The files of patients with peritoneal malignancy who underwent CRS + HIPEC from 2015–2022 were retrieved. Morbidity and hospital mortality were recorded and correlated to a variety of clinical variables.Results A total of 44/192 (22.9%) patients were recorded with postoperative complications. Grade 3 and 4 complications were 12.5%. The prognostic variables of morbidity were the extent of peritoneal malignancy and the number of suture lines. The mortality rate was 2.5% (5 patients). The number of FFP units, and peritonectomy procedures were identified as prognostic variables of hospital mortality.Conclusions The morbidity rate in patients undergoing CRS + HIPEC is acceptable. The prognostic variables of morbidity are the extent of peritoneal malignancy, and the number of suture lines. The mortality rate is low. The prognostic variables of mortality are the number of FFP units, and the number of peritonectomy procedures.